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It was found out that naltrexone and bupropion combined, that could be marketed down the road as Contrave, provide better weight loss results than dieting and exercise alone.

Using two separate drugs to lose weight can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with weight-loss and the people who go through it one should err on the side of caution and allow the FDA do its job and demand some research be done so that the public recognizes the side effects and perils associated with the medications before we drive them. Keep in mind that drug companies are in business to generate money and that they would say everything to keep people on their medications.

Researchers found out that participants taking this drug for a year, lost excess weight within four weeks and have kept the body weight off through the entire 56 weeks from the study. Contrave can be a combination in the drugs naltrexone and bupropion, which appears to reflect a fresh trend of weight-loss drugs which might be made up of several active ingredient, which may make them more potent and safer.

Combo-pilling is the newest fad or also the newest to come under scrutiny and thus it is just more publicly known recently, comb-pilling for weight loss has been around since the eighties. The biggest reason that by using a combination of pills is becoming popular is the fact that as of right now there aren't any long term prescription weight loss supplements that have been licensed by the FDA other than orlistat. The truly disturbing part is doctors are prescribing these combinations of medications however some of the combinations happen to be rejected or have yet to be authorized by the FDA.

Seizures are a side effect with Contrave and really should not be taken in people who have seizure disorders. The drug could also raise hypertension and heartrate, and must not be used in individuals with a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise blood pressure and heartrate and must not used in patients with uncontrolled high blood pressure levels, in addition to by a person with heart-related and cerebrovascular (circulation system dysfunction impacting the brain) disease. Patients which has a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes with a boxed warning to alert health care professionals and patients for the increased chance of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for quitting smoking.

Approving a drug using this many potentially lethal unwanted side effects is inconsistent using the mission statement with the FDA. The power with the drug manufacturing lobby is blatantly evident inside the approval of several drugs requiring 'post-marketing' studies which are clearly significant to overall drug safety inside US.